Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, Yan N. Crystal structure of a bacterial homologue of glucose transporters GLUT1–4. Nature, 2012; 490:361–366.
Yin P, Deng D, Yan C, Pan X, Xi JJ, Yan N*, Shi Y*.Specific DNA-RNA Hybrid Recognition by TAL Effectors. Cell Rep. 2012; Sep 26. Epub ahead of print (co-corresponding authors)
Deng D, Yin P, Yan C, Pan X, Gong X, Qi S, Xie T, Mahfouz M, Zhu JK, Yan N*, Shi Y*. Recognition of methylated DNA by TAL effectors. Cell Res. 2012;22(10):1502-4. (co-corresponding authors)
Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012;486(7401):130-4.
Tian Xie, Ruobing Ren, Yuan-yuan Zhang, Yuxuan Pang, Chuangye Yan, Xinqi Gong, Yuan He, Wenqi Li, Di Miao, Qi Hao, Haiteng Deng, Zhixin Wang, Jia-Wei Wu and Nieng Yan. Molecular Mechanism for Inhibition of a Critical Component in the Arabidopsis thaliana Abscisic Acid Signal Transduction Pathways, SnRK2.6, by Protein Phosphatase ABI1. J Biol Chem. 2012; 287:794-802.
Dong Deng, Chuangye Yan, Xiaojing Pan, Magdy Mahfouz, Jiawei Wang, Jian-Kang Zhu, Yigong Shi*, and Nieng Yan* Structural basis for the specific recognition of DNA by TAL effectors. Science. 2012; 335(6069):720-3, Epub: 2012 Jan 5. (* indicates corresponding authors).
Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu JZ, Wang J, Yan SF, Yan N. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins.Mol Cell. 2011;42(5):662-72.
Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, Deng D, Dang S, Zhang X, Wang J, Yan N. Structure and mechanism of the uracil transporter UraA. Nature. 2011;472(7342):243-6.
Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N. Structure of a fucose transporter in an outward-open conformation. Nature. 2010;467(7316):734-8.
Yuan X, Yin P, Hao Q, Yan C, Wang J, Yan N. Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2. J Biol Chem. 2010; 285(37):28953-8.
Hao Q, Yin P, Yan C, Yuan X, Li W, Zhang Z, Liu L, Wang J, Yan N. Functional mechanism of the abscisic acid agonist pyrabactin. J Biol Chem. 2010;285(37):28946-52.
Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J,Yan N*,Shi Y*. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446-57. (co-corresponding authors)
Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N*, Shi Y*. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature. 2009;462(7272):467-72. (co-corresponding authors)
Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009;16(12):1230-6. Prior to 2007
Yan N, Shi Y. Allosteric activation of a bacterial stress sensor. Cell. 2007;131(3):441-3.
Wu Z*, Yan N*, Feng L*, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.Nat Struct Mol Biol. 2006;13(12):1084-91.(co-first authors)
Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem. 2006;281(13):8667-74.
Yan N, Xu Y, Shi Y. 2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation. Cell Cycle. 2006;5(1):31-4.
Yan N, Shi Y. Mechanisms of apoptosis through structural biology. Annu Rev Cell Dev Biol. 2005; 21:35-56.
Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature. 2005; 437(7060):831-7.
Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol Cell. 2004; 15(6):999-1006.
Yan N, Wu JW, Chai J, Li W, Shi Y. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol. 2004;11(5):420-8.
Yan N, Shi Y. Histone H1.2 as a trigger for apoptosis. Nat Struct Biol. 2003;10(12):983-5.
Chai J*, Yan N*, Huh JR, Wu JW, Li W, Hay BA, Shi Y. Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat Struct Biol. 2003;10(11):892-8. (co-first authors)
2018年12月19日,颜宁应邀访问山东大学青岛校区,作了题为“How is electrical signal generated? Structure and mechanistic investigations of Nav channels”的学术报告,并为本科生上了一堂科普课。她在报告中指出钠离子电压门控通道在兴奋性细胞中参与维持静息电位和动作电位的发生,与正常的生理功能调控以及疾病的发生密切相关。颜宁从钠离子通道的结构入手,首先解析了细菌中的钠离子通道NavRh的结构,随着冷冻电镜技术的革新,进一步解析了真核生物蟑螂和电鳗的钠离子通道结构,以及人的Nav1.4通道的结构;分享了在解析人的Nav1.4通道的结构中遇到的瓶颈和解决思路,重点谈到优化膜蛋白Nav1.4的蛋白性质和解决冷冻电镜样品制备中蛋白变性问题;修正了传统的钠离子通道活性调控的“Ball and Chain”模型,提出了变构阻断机制 [5] 。
美国艺术与科学院(又译为美国人文与科学院、美国文理科学院,英语:American Academy of Arts and Sciences,简称AAAS)是美国历史最悠久的院士机构及地位最为崇高的荣誉团体之一,也是进行独立政策研究的学术中心。自从约翰·亚当斯、约翰·汉考克、詹姆斯·鲍登及其他的建国先贤于独立战争期间创立美国艺术与科学院以来,当选为其院士一直被认为是美国的最高荣誉之一。 [3]
美国艺术与科学院建立之时,美国正在法国等国的协助下与英国作战,所以美国的创立者选择比照包括作家、人文学人、科学家、军事家、政治家在内的法兰西学术院,而不是仅涵盖自然科学的英国皇家学会,建立新大陆的学术院,并在正式名称中选用“Arts and Sciences”一词表示其覆盖全部学术和专业领域。“Arts and Sciences”有多种中文译法,包括“艺术与科学”、“人文与科学”、“文理科学”等。
美国艺术与科学院的创院院士包括:Samuel Adams, John Adams, John Bacon, James Bowdoin, Charles Chauncy, John Clark, David Cobb, Samuel Cooper, Thomas Cushing, Nathan Cushing, William Cushing, Tristram Dalton, Francis Dana, Samuel Deane, Perez Fobes, Caleb Gannett, Henry Gardner, Benjamin Guild, John Hancock, Joseph Hawley, Edward Augustus Holyoke, Ebenezer Hunt, Jonathan Jackson, Charles Jarvis, Samuel Langdon, Levi Lincoln, Daniel Little, Elijah Lothrup, John Lowell, Samuel Mather, Samuel Moody, Andrew Oliver, Joseph Orne, Theodore Parsons, George Partridge, Robert Treat Paine, Phillips Payson, Samuel Phillips, Jr., John Pickering, Oliver Prescott, Zedekiah Sanger, Nathaniel Peaslee Sargeant, Micajah Sawyer, Theodore Sedgwick, William Sever, Stephen Sewall, David Sewall, John Sprague, Ebenezer Storer, Caleb Strong, James Sullivan, John Bernard Sweat, Nathaniel Tracy, Cotton Tufts, James Warren, Samuel West, Edward Wigglesworth, Joseph Willard, Samuel Williams, Abraham Williams, Nehemiah Williams, and James Winthrop.
(美国普林斯顿大学教授、美国科学院外籍院士)
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颜宁,女,1977年11月出生于山东章丘 [1] ,结构生物学家 [2] ,美国国家科学院外籍院士 [3] 、美国艺术与科学院院士 [28] ,美国霍华德休斯医学研究所首届“国际青年科学家” [4] ,美国普林斯顿大学教授、博士生导师 [1] ,清华大学生命科学学院兼职教授 [5] 。
颜宁于1996年-2000年,在清华大学生物科学与技术系学习,获学士学位;2000年-2004年,在美国普林斯顿大学分子生物学系学习,获博士学位;2005年-2007年,在美国普林斯顿大学分子生物学系从事博士后研究;2007年-2017年,任清华大学教授、博士生导师;2017年5月7日,已接受美国普林斯顿大学邀请,受聘普林斯顿大学分子生物学系雪莉·蒂尔曼终身讲席教授的职位 [6-7] ;2019年4月当选美国国家科学院外籍院士 [3] ;2021年4月当选美国艺术与科学院院士。 [28]
颜宁主要从事与疾病相关的重要膜转运蛋白、电压门控离子通道的结构与工作机理及膜蛋白调控胆固醇代谢通路的分子机制方面的研究 [8] 。